The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a developmentally distinct extracellular state

The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a developmentally distinct extracellular state

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Orientia tsutsugamushi (Ot) the causing agent of scrub typhus exits infected cells using a unique mechanism that involves budding off the surface of infected cells.Here, Atwal et al.report that Ots that have budded grip with wire from their host cells are in a distinct developmental stage than intracellular bacteria and provide the first characterization of this extracellular stage.Both forms are infectious but differ in their physical properties, proteome, and entry mechanism Gas Cylinder Adaptor into host cells.